Caseware UK (AP4) 2024.0.164 2024.0.164 2024-12-312024-12-31true2024-01-01falseImmunology research4439falseThe members have not required the company to obtain an audit in accordance with section 476 of the Companies Act 2006.false 03873386 2024-01-01 2024-12-31 03873386 2023-01-01 2023-12-31 03873386 2024-12-31 03873386 2023-12-31 03873386 2024-01-01 03873386 c:Director2 2024-01-01 2024-12-31 03873386 d:Buildings 2024-01-01 2024-12-31 03873386 d:Buildings 2024-12-31 03873386 d:Buildings 2023-12-31 03873386 d:Buildings d:OwnedOrFreeholdAssets 2024-01-01 2024-12-31 03873386 d:PlantMachinery 2024-01-01 2024-12-31 03873386 d:PlantMachinery 2024-12-31 03873386 d:PlantMachinery 2023-12-31 03873386 d:PlantMachinery d:OwnedOrFreeholdAssets 2024-01-01 2024-12-31 03873386 d:OfficeEquipment 2024-01-01 2024-12-31 03873386 d:OfficeEquipment 2024-12-31 03873386 d:OfficeEquipment 2023-12-31 03873386 d:OfficeEquipment d:OwnedOrFreeholdAssets 2024-01-01 2024-12-31 03873386 d:OtherPropertyPlantEquipment 2024-01-01 2024-12-31 03873386 d:OtherPropertyPlantEquipment 2024-12-31 03873386 d:OtherPropertyPlantEquipment 2023-12-31 03873386 d:OtherPropertyPlantEquipment d:OwnedOrFreeholdAssets 2024-01-01 2024-12-31 03873386 d:OwnedOrFreeholdAssets 2024-01-01 2024-12-31 03873386 d:FreeholdInvestmentProperty 2024-01-01 2024-12-31 03873386 d:FreeholdInvestmentProperty 2024-12-31 03873386 d:CurrentFinancialInstruments 2024-12-31 03873386 d:CurrentFinancialInstruments 2023-12-31 03873386 d:Non-currentFinancialInstruments 2024-12-31 03873386 d:Non-currentFinancialInstruments 2023-12-31 03873386 d:CurrentFinancialInstruments d:WithinOneYear 2024-12-31 03873386 d:CurrentFinancialInstruments d:WithinOneYear 2023-12-31 03873386 d:Non-currentFinancialInstruments d:AfterOneYear 2024-12-31 03873386 d:Non-currentFinancialInstruments d:AfterOneYear 2023-12-31 03873386 d:ShareCapital 2024-12-31 03873386 d:ShareCapital 2023-12-31 03873386 d:CapitalRedemptionReserve 2024-12-31 03873386 d:CapitalRedemptionReserve 2023-12-31 03873386 d:RetainedEarningsAccumulatedLosses 2024-12-31 03873386 d:RetainedEarningsAccumulatedLosses 2023-12-31 03873386 c:OrdinaryShareClass1 2024-01-01 2024-12-31 03873386 c:OrdinaryShareClass1 2024-12-31 03873386 c:OrdinaryShareClass1 2023-12-31 03873386 c:OrdinaryShareClass2 2024-01-01 2024-12-31 03873386 c:OrdinaryShareClass2 2024-12-31 03873386 c:OrdinaryShareClass2 2023-12-31 03873386 c:OrdinaryShareClass3 2024-01-01 2024-12-31 03873386 c:OrdinaryShareClass3 2024-12-31 03873386 c:OrdinaryShareClass3 2023-12-31 03873386 c:OrdinaryShareClass4 2024-01-01 2024-12-31 03873386 c:OrdinaryShareClass4 2024-12-31 03873386 c:OrdinaryShareClass4 2023-12-31 03873386 c:FRS102 2024-01-01 2024-12-31 03873386 c:AuditExempt-NoAccountantsReport 2024-01-01 2024-12-31 03873386 c:FullAccounts 2024-01-01 2024-12-31 03873386 c:PrivateLimitedCompanyLtd 2024-01-01 2024-12-31 03873386 d:Subsidiary1 2024-12-31 03873386 d:Subsidiary1 2024-01-01 2024-12-31 03873386 d:Subsidiary1 1 2024-01-01 2024-12-31 03873386 2 2024-01-01 2024-12-31 03873386 6 2024-01-01 2024-12-31 03873386 d:AcceleratedTaxDepreciationDeferredTax 2024-12-31 03873386 d:AcceleratedTaxDepreciationDeferredTax 2023-12-31 03873386 d:TaxLossesCarry-forwardsDeferredTax 2024-12-31 03873386 d:TaxLossesCarry-forwardsDeferredTax 2023-12-31 03873386 e:PoundSterling 2024-01-01 2024-12-31 xbrli:shares iso4217:GBP xbrli:pure
Registered number: 03873386


PROIMMUNE LIMITED








UNAUDITED

FINANCIAL STATEMENTS

FOR THE YEAR ENDED 31 DECEMBER 2024

 
PROIMMUNE LIMITED
REGISTERED NUMBER: 03873386

BALANCE SHEET
AS AT 31 DECEMBER 2024

2024
2023
£
£

Fixed assets
  

Tangible assets
 5 
7,515,466
1,060,935

Investments
 6 
121,400
121,400

Investment property
 7 
3,867,563
-

  
11,504,429
1,182,335

Current assets
  

Debtors: amounts falling due within one year
 8 
817,343
953,049

Current asset investments
 9 
53,880,396
51,117,190

Cash at bank and in hand
 10 
1,031,967
870,830

  
55,729,706
52,941,069

Creditors: amounts falling due within one year
 11 
(1,269,092)
(867,943)

Net current assets
  
 
 
54,460,614
 
 
52,073,126

Total assets less current liabilities
  
65,965,043
53,255,461

Creditors: amounts falling due after more than one year
 12 
(58,007)
-

Provisions for liabilities
  

Deferred tax
 13 
(7,306,677)
(4,851,506)

  
 
 
(7,306,677)
 
 
(4,851,506)

Net assets
  
58,600,359
48,403,955


Capital and reserves
  

Called up share capital 
 14 
2,003
2,003

Capital redemption reserve
  
58
58

Profit and loss account
  
58,598,298
48,401,894

  
58,600,359
48,403,955


Page 1

 
PROIMMUNE LIMITED
REGISTERED NUMBER: 03873386
    
BALANCE SHEET (CONTINUED)
AS AT 31 DECEMBER 2024

The directors consider that the Company is entitled to exemption from audit under section 477 of the Companies Act 2006 and members have not required the Company to obtain an audit for the year in question in accordance with section 476 of the Companies Act 2006.

The directors acknowledge their responsibilities for complying with the requirements of the Companies Act 2006 with respect to accounting records and the preparation of financial statements.

The financial statements have been prepared in accordance with the provisions applicable to companies subject to the small companies regime and in accordance with the provisions of FRS 102 Section 1A - small entities.

The financial statements have been delivered in accordance with the provisions applicable to companies subject to the small companies regime.

The Company has opted not to file the statement of comprehensive income in accordance with provisions applicable to companies subject to the small companies' regime.

The financial statements were approved and authorised for issue by the board and were signed on its behalf by: 




................................................
Dr N Schwabe
Director

Date: 28 September 2025

The notes on pages 3 to 16 form part of these financial statements.

Page 2

 
PROIMMUNE LIMITED
 
 
 
NOTES TO THE FINANCIAL STATEMENTS
FOR THE YEAR ENDED 31 DECEMBER 2024

1.


General information

Proimmune Limited is a private Company limited by share capital and incorporated in England and Wales.
The registered office and principal place of business is Magdalen Centre, Oxford Science Park, Oxford, Oxfordshire, OX4 4GA.

2.Accounting policies

 
2.1

Basis of preparation of financial statements

The financial statements have been prepared under the historical cost convention unless otherwise specified within these accounting policies and in accordance with FRS 102 'The Financial Reporting Standard applicable in the UK and the Republic of Ireland' and the requirements of the Companies Act 2006. The disclosure requirements of Section 1A of FRS 102 have been applied other than where additional disclosure is required to show a true and fair view.

The following principal accounting policies have been applied:

 
2.2

Foreign currency translation

Functional and presentation currency

The Company's functional and presentational currency is GBP.

Transactions and balances

Foreign currency transactions are translated into the functional currency using the spot exchange rates at the dates of the transactions.

At each period end foreign currency monetary items are translated using the closing rate. Non-monetary items measured at historical cost are translated using the exchange rate at the date of the transaction and non-monetary items measured at fair value are measured using the exchange rate when fair value was determined.

Foreign exchange gains and losses resulting from the settlement of transactions and from the translation at period-end exchange rates of monetary assets and liabilities denominated in foreign currencies are recognised in profit or loss except when deferred in other comprehensive income as qualifying cash flow hedges.

Foreign exchange gains and losses that relate to borrowings and cash and cash equivalents are presented in the Statement of comprehensive income within 'finance income or costs'. All other foreign exchange gains and losses are presented in profit or loss within 'other operating income'.

Page 3

 
PROIMMUNE LIMITED
 
 
 
NOTES TO THE FINANCIAL STATEMENTS
FOR THE YEAR ENDED 31 DECEMBER 2024

2.Accounting policies (continued)

 
2.3

Revenue

Revenue is recognised to the extent that it is probable that the economic benefits will flow to the Company and the revenue can be reliably measured. Revenue is measured as the fair value of the consideration received or receivable, excluding discounts, rebates, value added tax and other sales taxes. The following criteria must also be met before revenue is recognised:

Sale of goods

Revenue from the sale of goods is recognised when all of the following conditions are satisfied:
the Company has transferred the significant risks and rewards of ownership to the buyer;
the Company retains neither continuing managerial involvement to the degree usually associated with ownership nor effective control over the goods sold;
the amount of revenue can be measured reliably;
it is probable that the Company will receive the consideration due under the transaction; and
the costs incurred or to be incurred in respect of the transaction can be measured reliably.

Rendering of services

Revenue from a contract to provide services is recognised in the period in which the services are provided in accordance with the stage of completion of the contract when all of the following conditions are satisfied:
the amount of revenue can be measured reliably;
it is probable that the Company will receive the consideration due under the contract;
the stage of completion of the contract at the end of the reporting period can be measured reliably; and
the costs incurred and the costs to complete the contract can be measured reliably.

 
2.4

Operating leases: the Company as lessor

Rental income from operating leases is credited to profit or loss on a straight-line basis over the lease term.

Amounts paid and payable as an incentive to sign an operating lease are recognised as a reduction to income over the lease term on a straight-line basis, unless another systematic basis is representative of the time pattern over which the lessor's benefit from the leased asset is diminished.

 
2.5

Operating leases: the Company as lessee

Rentals paid under operating leases are charged to profit or loss on a straight-line basis over the lease term.

Benefits received and receivable as an incentive to sign an operating lease are recognised on a straight-line basis over the lease term, unless another systematic basis is representative of the time pattern of the lessee's benefit from the use of the leased asset.

Page 4

 
PROIMMUNE LIMITED
 
 
 
NOTES TO THE FINANCIAL STATEMENTS
FOR THE YEAR ENDED 31 DECEMBER 2024

2.Accounting policies (continued)

 
2.6

Research and development

In the research phase of an internal project it is not possible to demonstrate that the project will generate future economic benefits and hence all expenditure on research shall be recognised as an expense when it is incurred. Intangible assets are recognised from the development phase of a project if and only if certain specific criteria are met in order to demonstrate the asset will generate probable future economic benefits and that its cost can be reliably measured. The capitalised development costs are subsequently amortised on a straight-line basis over their useful economic lives, which range from 3 to 6 years.
If it is not possible to distinguish between the research phase and the development phase of an internal project, the expenditure is treated as if it were all incurred in the research phase only.

 
2.7

Interest income

Interest income is recognised in profit or loss using the effective interest method.

 
2.8

Finance costs

Finance costs are charged to profit or loss over the term of the debt using the effective interest method so that the amount charged is at a constant rate on the carrying amount. Issue costs are initially recognised as a reduction in the proceeds of the associated capital instrument.

 
2.9

Pensions

The Company contributes to a defined contribution plan for its employees. A defined contribution plan is a pension plan under which the Company pays fixed contributions into a separate entity. Once the contributions have been paid the Company has no further payment obligations.
The contributions are recognised as an expense in profit or loss when they fall due. Amounts not paid are shown in accruals as a liability in the Balance sheet. The assets of the plan are held separately from the Company in independently administered funds.

Page 5

 
PROIMMUNE LIMITED
 
 
 
NOTES TO THE FINANCIAL STATEMENTS
FOR THE YEAR ENDED 31 DECEMBER 2024

2.Accounting policies (continued)

 
2.10

Current and deferred taxation

The tax expense for the year comprises current and deferred tax. Tax is recognised in profit or loss except that a charge attributable to an item of income and expense recognised as other comprehensive income or to an item recognised directly in equity is also recognised in other comprehensive income or directly in equity respectively.

The current income tax charge is calculated on the basis of tax rates and laws that have been enacted or substantively enacted by the balance sheet date in the countries where the Company operates and generates income.

Deferred tax balances are recognised in respect of all timing differences that have originated but not reversed by the balance sheet date, except that:
The recognition of deferred tax assets is limited to the extent that it is probable that they will be recovered against the reversal of deferred tax liabilities or other future taxable profits; and
Any deferred tax balances are reversed if and when all conditions for retaining associated tax allowances have been met.

Deferred tax balances are not recognised in respect of permanent differences except in respect of business combinations, when deferred tax is recognised on the differences between the fair values of assets acquired and the future tax deductions available for them and the differences between the fair values of liabilities acquired and the amount that will be assessed for tax. Deferred tax is determined using tax rates and laws that have been enacted or substantively enacted by the balance sheet date.


Page 6

 
PROIMMUNE LIMITED
 
 
 
NOTES TO THE FINANCIAL STATEMENTS
FOR THE YEAR ENDED 31 DECEMBER 2024

2.Accounting policies (continued)

 
2.11

Tangible fixed assets

Tangible fixed assets under the cost model are stated at historical cost less accumulated depreciation and any accumulated impairment losses. Historical cost includes expenditure that is directly attributable to bringing the asset to the location and condition necessary for it to be capable of operating in the manner intended by management.

Depreciation is charged so as to allocate the cost of assets less their residual value over their estimated useful lives, using the straight-line method.

Depreciation is provided on the following basis:

Freehold property
-
2%
straight-line method
Lab equipment
-
25%
straight-line method
Office equipment
-
25%
straight-line method
Computer software
-
50%
straight-line method

The assets' residual values, useful lives and depreciation methods are reviewed, and adjusted prospectively if appropriate, or if there is an indication of a significant change since the last reporting date.

Gains and losses on disposals are determined by comparing the proceeds with the carrying amount and are recognised in profit or loss.

 
2.12

Investment property

Investment property is carried at fair value determined annually by external valuers and derived from the current market rents and investment property yields for comparable real estate, adjusted if necessary for any difference in the nature, location or condition of the specific asset. No depreciation is provided. Changes in fair value are recognised in profit or loss.

 
2.13

Valuation of investments

Investments in subsidiaries are measured at cost less accumulated impairment.

Investments in unlisted Company shares, whose market value can be reliably determined, are remeasured to market value at each balance sheet date. Gains and losses on remeasurement are recognised in the Statement of comprehensive income for the period. Where market value cannot be reliably determined, such investments are stated at historic cost less impairment.

Investments in listed company shares are remeasured to market value at each balance sheet date. Gains and losses on remeasurement are recognised in profit or loss for the period.

 
2.14

Debtors

Short-term debtors are measured at transaction price, less any impairment. Loans receivable are measured initially at fair value, net of transaction costs, and are measured subsequently at amortised cost using the effective interest method, less any impairment.

Page 7

 
PROIMMUNE LIMITED
 
 
 
NOTES TO THE FINANCIAL STATEMENTS
FOR THE YEAR ENDED 31 DECEMBER 2024

2.Accounting policies (continued)

 
2.15

Cash and cash equivalents

Cash is represented by cash in hand and deposits with financial institutions repayable without penalty on notice of not more than 24 hours. Cash equivalents are highly liquid investments that mature in no more than three months from the date of acquisition and that are readily convertible to known amounts of cash with insignificant risk of change in value.

 
2.16

Creditors

Short-term creditors are measured at the transaction price. Other financial liabilities, including bank loans, are measured initially at fair value, net of transaction costs, and are measured subsequently at amortised cost using the effective interest method.

 
2.17

Provisions for liabilities

Provisions are recognised when an event has taken place that gives rise to a legal or constructive obligation, a transfer of economic benefits is probable and a reliable estimate can be made.
Provisions are measured as the best estimate of the amount required to settle the obligation, taking into account the related risks and uncertainties.
 
Deferred tax liabilities are also presented within provisions but are measured in accordance with the accounting policy on taxation.
 
Increases in provisions are generally charged as an expense to profit or loss.

 
2.18

Dividends

Equity dividends are recognised when they become legally payable.

Page 8

 
PROIMMUNE LIMITED
 
 
 
NOTES TO THE FINANCIAL STATEMENTS
FOR THE YEAR ENDED 31 DECEMBER 2024

3.


Judgments in applying accounting policies and key sources of estimation uncertainty

Estimates and judgments are continually evaluated and are based on historical experience and other factors, including expectations of future events that are believed to be reasonable under the circumstances. The key judgments are as follows:-
Valuation of tangible fixed assets:
Tangible fixed assets are depreciated over their useful economic life taking into account, where appropriate, residual values. Assessment of useful lives and residual values are performed annually. In assessing the residual  values, the remaining life of the asset, its projected disposal value and future market conditions are taken into account.
Fixed asset investments:
Fixed asset investments are held at fair value in the accounts. Annual impairment reviews are carried out to ensure that such investments are not held above their recoverable amounts in the accounts of the Company. When reviewing the value of fixed asset investments, an assessment is made as to the valuation by reference to the future expected benefits deriving from the investments. 
Provisions for bad debts:
A general bad debt provisions exists by reference to ageing periods of the associated debts, where possible taking in to account past performance and an assessment of future market conditions.


4.


Employees

The average monthly number of employees, including directors, during the year was 44 (2023 - 39).

Page 9

 
PROIMMUNE LIMITED
 
 
 
NOTES TO THE FINANCIAL STATEMENTS
FOR THE YEAR ENDED 31 DECEMBER 2024

5.


Tangible fixed assets





Freehold property
Plant and machinery
Office equipment
Other fixed assets
Total

£
£
£
£
£



Cost or valuation


At 1 January 2024
-
2,220,546
199,229
3,282
2,423,057


Additions
6,437,695
394,221
7,369
-
6,839,285


Disposals
-
(756,556)
(155,453)
-
(912,009)



At 31 December 2024

6,437,695
1,858,211
51,145
3,282
8,350,333



Depreciation


At 1 January 2024
-
1,189,912
168,928
3,282
1,362,122


Charge for the year on owned assets
-
371,329
11,130
-
382,459


Disposals
-
(754,261)
(155,453)
-
(909,714)



At 31 December 2024

-
806,980
24,605
3,282
834,867



Net book value



At 31 December 2024
6,437,695
1,051,231
26,540
-
7,515,466



At 31 December 2023
-
1,030,634
30,301
-
1,060,935

Page 10

 
PROIMMUNE LIMITED
 
 
 
NOTES TO THE FINANCIAL STATEMENTS
FOR THE YEAR ENDED 31 DECEMBER 2024

6.


Fixed asset investments





Investments in subsidiary companies

£



Cost or valuation


At 1 January 2024
121,400



At 31 December 2024
121,400





Subsidiary undertaking


The following was a subsidiary undertaking of the Company:

Name

Class of shares

Holding

Proimmune INC
Ordinary
100%

The aggregate of the share capital and reserves as at 31 December 2024 and the profit or loss for the year ended on that date for the subsidiary undertaking were as follows:

Name
Aggregate of share capital and reserves
Profit/
(Loss)

Proimmune INC
194,376
(788)

Page 11

 
PROIMMUNE LIMITED
 
 
 
NOTES TO THE FINANCIAL STATEMENTS
FOR THE YEAR ENDED 31 DECEMBER 2024

7.


Investment property


Freehold investment property

£



Valuation


Additions at cost
3,867,563



At 31 December 2024
3,867,563

The 2024 valuations were made by Directors, on an open market value for existing use basis.

The investment property was acquired during the financial reporting period, and as such the price paid is deemed to be market value at the balance sheet date.






8.


Debtors

2024
2023
£
£


Trade debtors
435,150
712,452

Amounts owed by group undertakings
-
79,752

Other debtors
374,073
149,421

Prepayments and accrued income
8,120
11,424

817,343
953,049


Page 12

 
PROIMMUNE LIMITED
 
 
 
NOTES TO THE FINANCIAL STATEMENTS
FOR THE YEAR ENDED 31 DECEMBER 2024

9.


Current asset investments

2024
2023
£
£

Listed investments
53,880,396
51,117,190

53,880,396
51,117,190


2024
2023
£
£


Opening fair value
51,117,190
39,693,474

Purchases
1,014,879
3,980,848

Sales
(7,876,752)
-

Gains/(Losses) on remeasurement to fair value
9,625,080
7,442,868

Market value
53,880,397
51,117,190





10.


Cash and cash equivalents

2024
2023
£
£

Cash at bank and in hand
1,031,967
870,830

1,031,967
870,830



11.


Creditors: Amounts falling due within one year

2024
2023
£
£

Payments received on account
214,399
270,105

Trade creditors
686,533
390,876

Amounts owed to group undertakings
299,311
-

Corporation tax
-
145,774

Other taxation and social security
43,014
37,210

Other creditors
20,455
18,993

Accruals and deferred income
5,380
4,985

1,269,092
867,943


Page 13

 
PROIMMUNE LIMITED
 
 
 
NOTES TO THE FINANCIAL STATEMENTS
FOR THE YEAR ENDED 31 DECEMBER 2024

12.


Creditors: Amounts falling due after more than one year

2024
2023
£
£

Other creditors
58,007
-

58,007
-


The aggregate amount of liabilities repayable wholly or in part more than five years after the balance sheet date is:

2024
2023
£
£


Repayable other than by instalments
58,007
-

58,007
-

The above balance relates to a lease deposit held, the balance is repaybale on cessation of the underlying agreement.

Page 14

 
PROIMMUNE LIMITED
 
 
 
NOTES TO THE FINANCIAL STATEMENTS
FOR THE YEAR ENDED 31 DECEMBER 2024

13.


Deferred taxation




2024


£






At beginning of year
(4,851,506)


Utilised in year
(2,455,171)



At end of year
(7,306,677)

The provision for deferred taxation is made up as follows:

2024
2023
£
£


Accelerated capital allowances and other temporary timing differences
(8,306,394)
(4,851,506)

Tax losses carried forward
999,717
-

(7,306,677)
(4,851,506)


14.


Share capital

2024
2023
£
£
Allotted, called up and fully paid



100,002 (2023 - 100,002) Ordinary A shares of £0.01 each
1,000
1,000
330 (2023 - 330) Ordinary B shares of £0.01 each
3
3
50 (2023 - 50) Ordinary C shares of £10.00 each
500
500
50 (2023 - 50) Ordinary D shares of £10.00 each
500
500

2,003

2,003



15.


Pension commitments

The Company contributes into a defined contributions pension scheme. The assets of the scheme are held separately from those of the Company in an independently administered fund. The pension cost charge represents contributions payable by the Company  to the fund and amounted to £280,974 (2023 - £30,740). At 31 December 2024, £9,734 was payable to the scheme (2023 - £8,490).

Page 15

 
PROIMMUNE LIMITED
 
 
 
NOTES TO THE FINANCIAL STATEMENTS
FOR THE YEAR ENDED 31 DECEMBER 2024

16.


Related party transactions

During the year Proimmune Limited made sales of £1,835,858 (2023 - £2,923,425) and recharged management and other expenses of £166,708 (2023 - £361,581) to Proimmune Inc (a 100% subsidiary). At the balance sheet date the company owed £299,311 to Proimmune Inc (2023 - was owed £79,752).
At 31 December 2024 the Company had a Directors loan creditor of £4,607 (2023 - debtor of £1,319). Interest is charged on Directors loans and they have no fixed repayment date.


17.


Controlling party

The Directors consider Mr C Guilbert and Mr M Jefferies to be the ultimate controlling parties through
their control of The Provident Foundation.
The Company was under the immediate control of The Provident Foundation at the close of the current
year.

 
Page 16