IRIS Accounts Production v26.1.10.61 Other Company accounts True false Pounds 1.9.24 31.8.25 31.8.25 FY FRS 102 Independent examiner Small companies regime for accounts Full Charities SORP true true true true false true false true iso4217:GBP iso4217:USD iso4217:EUR xbrli:shares xbrli:pure utr:tonnes utr:kWh 06996068 2024-08-31 06996068 2025-08-31 06996068 2024-09-01 2025-08-31 06996068 2023-08-31 06996068 2023-09-01 2024-08-31 06996068 2024-08-31 06996068 ns0:CharitableCompanyLimitedByGuarantee 2024-09-01 2025-08-31 06996068 ns15:PoundSterling 2024-09-01 2025-08-31 06996068 ns11:FRS102 2024-09-01 2025-08-31 06996068 ns0:IndependentExaminationCharity 2024-09-01 2025-08-31 06996068 ns11:SmallCompaniesRegimeForAccounts 2024-09-01 2025-08-31 06996068 ns11:FullAccounts 2024-09-01 2025-08-31 06996068 ns0:CharitiesSORP 2024-09-01 2025-08-31 06996068 ns16:EnglandWales 2024-09-01 2025-08-31 06996068 ns11:RegisteredOffice 2024-09-01 2025-08-31 06996068 ns0:Trustee2 2024-09-01 2025-08-31 06996068 ns0:Trustee1 2024-09-01 2025-08-31 06996068 ns0:Trustee3 2024-09-01 2025-08-31 06996068 ns0:Trustee4 2024-09-01 2025-08-31 06996068 ns0:Trustee5 2024-09-01 2025-08-31 06996068 ns0:Trustee6 2024-09-01 2025-08-31 06996068 ns0:Trustee7 2024-09-01 2025-08-31 06996068 ns0:Trustee8 2024-09-01 2025-08-31 06996068 ns0:Trustee9 2024-09-01 2025-08-31 06996068 ns0:Trustee10 2024-09-01 2025-08-31 06996068 ns0:Trustee11 2024-09-01 2025-08-31 06996068 ns11:CompanySecretary1 2024-09-01 2025-08-31 06996068 ns0:TotalUnrestrictedFunds 2024-09-01 2025-08-31 06996068 ns0:TotalRestrictedIncomeFunds 2024-09-01 2025-08-31 06996068 ns0:Activity8 2024-09-01 2025-08-31 06996068 ns0:Activity8 ns0:TotalUnrestrictedFunds 2024-09-01 2025-08-31 06996068 ns0:Activity8 ns0:TotalRestrictedIncomeFunds 2024-09-01 2025-08-31 06996068 ns0:Activity8 2023-09-01 2024-08-31 06996068 ns0:Activity9 2024-09-01 2025-08-31 06996068 ns0:Activity9 ns0:TotalUnrestrictedFunds 2024-09-01 2025-08-31 06996068 ns0:Activity9 ns0:TotalRestrictedIncomeFunds 2024-09-01 2025-08-31 06996068 ns0:Activity9 2023-09-01 2024-08-31 06996068 ns0:Activity11 2024-09-01 2025-08-31 06996068 ns0:Activity11 ns0:TotalUnrestrictedFunds 2024-09-01 2025-08-31 06996068 ns0:Activity11 ns0:TotalRestrictedIncomeFunds 2024-09-01 2025-08-31 06996068 ns0:Activity11 2023-09-01 2024-08-31 06996068 ns0:TotalUnrestrictedFunds 2024-08-31 06996068 ns0:TotalRestrictedIncomeFunds 2024-08-31 06996068 ns0:TotalUnrestrictedFunds 2025-08-31 06996068 ns0:TotalRestrictedIncomeFunds 2025-08-31 06996068 ns0:TotalUnrestrictedFunds ns10:WithinOneYear 2025-08-31 06996068 ns0:TotalRestrictedIncomeFunds ns10:WithinOneYear 2025-08-31 06996068 ns10:WithinOneYear 2025-08-31 06996068 ns10:WithinOneYear 2024-08-31 06996068 2 2024-09-01 2025-08-31 06996068 ns0:GBP80001ToGBP90000 2024-09-01 2025-08-31 06996068 ns0:GBP80001ToGBP90000 2023-09-01 2024-08-31 06996068 ns0:TotalUnrestrictedFunds 2023-09-01 2024-08-31 06996068 ns0:TotalRestrictedIncomeFunds 2023-09-01 2024-08-31 06996068 ns0:Activity8 ns0:TotalUnrestrictedFunds 2023-09-01 2024-08-31 06996068 ns0:Activity8 ns0:TotalRestrictedIncomeFunds 2023-09-01 2024-08-31 06996068 ns0:Activity9 ns0:TotalUnrestrictedFunds 2023-09-01 2024-08-31 06996068 ns0:Activity9 ns0:TotalRestrictedIncomeFunds 2023-09-01 2024-08-31

REGISTERED COMPANY NUMBER: 06996068 (England and Wales)

REGISTERED CHARITY NUMBER: 1132984

| REPORT OF THE TRUSTEES AND |

| UNAUDITED FINANCIAL STATEMENTS |

| FOR THE YEAR ENDED 31ST AUGUST 2025 |

| FOR |

| THE INTERNATIONAL CML FOUNDATION |

THE INTERNATIONAL CML FOUNDATION

CONTENTS OF THE FINANCIAL STATEMENTS

FOR THE YEAR ENDED 31ST AUGUST 2025

| Page |

Report of the Trustees | 1 |  | to |  | 4

Independent Examiner's Report | 5 |

Statement of Financial Activities | 6 |

Balance Sheet | 7 |

Notes to the Financial Statements | 8 |  | to |  | 15

THE INTERNATIONAL CML FOUNDATION (REGISTERED NUMBER: 06996068)

REPORT OF THE TRUSTEES

FOR THE YEAR ENDED 31ST AUGUST 2025

The trustees who are also directors of the charity for the purposes of the Companies Act 2006, present their report with the financial statements of the charity for the year ended 31st August 2025. The trustees have adopted the provisions of Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) (effective 1 January 2019).

OBJECTIVES AND ACTIVITIES

Objectives and aims

The object of the Foundation is the advancement of health by the improvement of the treatment in all parts of the world of chronic myeloid leukaemia and related diseases (together "CML") and for the purpose of carrying out those general objects, the primary objects of the Foundation are in particular:-

(i) to improve clinical practice and disease monitoring in the treatment of CML

(ii) to support, encourage and promote research into the causes, prevention, study and treatment of CML

(iii) to promote and support the education of and disseminate knowledge amongst clinicians, scientists, health professionals and patients in matters concerning CML

(iv) to promote, foster and co-ordinate collaboration that is particularly (but not exclusively) international and is not only in the areas and activities of clinical practice disease monitoring and research into CML but also in any area or activity which is or may be conducive to the acceleration of the control and/or cure of CML

(v) to promote, set up, establish and support and share and exchange knowledge with other organisations whose objects are similar to these general or primary objects

(vi) to assist or promote any other charitable purposes which are related to these general and primary objects.

Significant activities

In furtherance of the objects, the Foundation has the following powers:-

(i) to promote or carry out research

(ii) to provide advice

(iii) to give and exchange information and advice and promote learning, study and research

(iv) to commission, publish, distribute and contribute to papers, books, periodicals, reports, leaflets, posters and other publications of any description

(v) to hold, attend and sponsor conferences, meetings, lectures, exhibitions and discussions

(vi) to raise funds and to apply for and solicit grants from pharmaceutical companies anywhere in the world.

Public benefit

The Trustees have considered their duty to have due regard to public benefit guidance published by the Commission and in their opinion, the foregoing report on the achievements and performance demonstrates that they have complied therewith.

THE INTERNATIONAL CML FOUNDATION (REGISTERED NUMBER: 06996068)

REPORT OF THE TRUSTEES

FOR THE YEAR ENDED 31ST AUGUST 2025

ACHIEVEMENTS AND PERFORMANCE

Charitable activities

The International CML Foundation (iCMLf) is a global charity working to improve the outcomes for people with chronic myeloid leukemia (CML), particularly in low- and middle-income countries (LMICs). Our mission is to foster global collaboration, share best practices, build clinical capacity, and accelerate research to ultimately find a cure for CML.

In 2024-2025, the iCMLf continued to address unmet needs in CML care and education by driving global research, enhancing medical education, and fostering access to expert guidance and clinical excellence.

SUMMARY OF CORE PROGRAMS AND IMPACT

1. Global Research

The iCMLf leads international collaborations that investigate critical questions to improve CML treatment, including:

- Big Data Projects: Through the Genomics Alliance and TFR (Treatment-Free Remission) Alliance, the Foundation is working to analyse over 3,400 datasets from 27 sites across 19 countries. These projects aim to understand genomic drivers of CML and improve the success rates of therapy discontinuation strategies.

- Research Publications: Three significant peer-reviewed studies were published this year, providing new insights into CML biolog y and management.

2. Education and Clinical Capacity Building

Physician education on clinical management and diagnostics remains a core focus for the iCMLf. Programs include:

- Knowledge Centre: Over 1,200 professionals accessed expert-led educational modules, including a new focus on fertility and pregnancy in CML.

- Regional Discussion Groups: Nine sessions held across three continents engaged 250 physicians from 44 countries, promoting regio n-specific dialogue and clinical learning.

- Clinical Conversations and Forums: These sessions facilitated global peer learning. Over 2,000 on-demand views were recorded across three key sessions.

- Publications and Case discussions: More than 8,000 views of challenging case discussions, including complex cases on pediatric relapse, pregnancy, and fourth-line therapies, provided practical guidance for clinicians.

- In-Person Events: iCMLf convened expert panels at major global events such as the John Goldman Conference, the Ame rican Society of Hematology meeting, and the Indian Cancer Congress.

3. Awareness, Recognition, and Advocacy

- iCMLf Prizes: Prestigious awards were presented to leaders in research, clinical practice, and patient advocacy.

- Patient Support: Programs and community engagements such as Friends of Max in India amplified patient voices and needs.

FINANCIAL REVIEW

Financial position

The financial position of the International CML Foundation remains solid.

Expenditure

- Total expenditure on programs: 67% on physician education, 11% on disease research, and 9% on patient support.

- 36% of all expenditures directly supported people with CML in LMICs.

- 13% was allocated to fundraising and 10% to governance.

Principal funding sources

The iCMLf works closely with industry and community partners to secure unrestricted grants and sponsorship for our programs and activities. The iCMLf requests donations through the iCMLf website.

Reserves policy

The reserves at the year end were £184,718 (2024 - £263,528). It is the policy of the Trustees to maintain sufficient reserves to ensure the day to day running of the Foundation. The level of reserves and current financial commitments are reviewed regularly at Trustees' meetings.The Foundation plans to hold a minimum of £150,000 as reserve funding. This is the amount for the foundation to operate without further income/outgoings for one year.

THE INTERNATIONAL CML FOUNDATION (REGISTERED NUMBER: 06996068)

REPORT OF THE TRUSTEES

FOR THE YEAR ENDED 31ST AUGUST 2025

FUTURE PLANS

The Trustees are proud of the iCMLf's achievements in 2024-2025. Our commitment to equity in CML care, global collaboration, and scientific innovation continues to drive tangible improvements in patient outcomes. Looking ahead, the iCMLf will build on the momentum of its current programs by expanding its research networks, launching new regionally focused education initiatives, and deepening engagement with patient communities. The Foundation remains focused on supporting clinicians and researchers worldwide as we work toward a cure for CML.

STRUCTURE, GOVERNANCE AND MANAGEMENT

Governing document

The charity is controlled by its governing document, a deed of trust, and constitutes a limited company, limited by guarantee, as defined by the Companies Act 2006.

Recruitment and appointment of new trustees

The power of appointing new or additional Trustees is vested in the existing Trustees. Prior to appointment, new Trustees would be introduced to the workings of the Foundation and advised of their responsibilities.

The iCMLf Board of Directors is composed of globally renowned hematologists and researchers who provide strategic leadership to the Foundation. To ensure diverse perspectives, the Board includes representatives from low- and middle-income countries, notably Brazil and India. In 2024, the iCMLf established a Patient Advisory Committee to strengthen patient representation within its work. This new committee brings together eight CML patients and advocates from five countries, who will collaborate with the Scientific Advisory Committee to help shape and support the Foundation's mission. The iCMLf's operations are managed by a multidisciplinary team based across Australia, the United Kingdom, Germany, the United States, and India.

Organisational structure

The Chief Executive reports to the eleven iCMLf Directors, specifically the iCMLf Chairman. The iCMLf Directors are supported by an Executive Committee of 3 directors and the Chief Executive.

The operational team; Communications Director, Communications Manager, Digital Media Officer, and Program Manager, report to the Chief Executive. In June 2024 a Development Manager was hired to join the operational team.

Strategic direction, financial review and budget approval are set at an annual iCMLf Directors meeting in September/October each year. Further planning and discussion meetings are held quarterly.

Strategic planning is assisted with an annual advisor's meeting. This includes the Scientific Advisory Committee and Patient Advisory Committee.The Patient Advisors also meet quarterly.

The operational team meets quarterly. The Communications Director/Communications Manager meet biweekly with the Chief Executive respectively. The Program Manager and Development Manager meet weekly with the Chief Executivefor business planning. The Chief Executive and iCMLf Chairman meet monthly.

Decisions are escalated from the operational team to the Chief Executive, iCMLf Chairman, iCMLf Executive Committee and iCMLf Board of Directors according to scale and impact.

REFERENCE AND ADMINISTRATIVE DETAILS

Registered Company number

06996068 (England and Wales)

Registered Charity number

1132984

Registered office

20 Eversley Road

Bexhill-on-Sea

East Sussex

TN40 1HE

THE INTERNATIONAL CML FOUNDATION (REGISTERED NUMBER: 06996068)

REPORT OF THE TRUSTEES

FOR THE YEAR ENDED 31ST AUGUST 2025

Trustees

Professor T P Hughes

Professor J Cortes Professor

Professor B Druker Professor

Professor A Hochhaus Professor

Professor J Radich Professor

Professor C Schiffer Professor

Professor J F Apperley DM FRCP/Path Professor

Professor M Mauro Professor

Professor G Saglio Professor

Dr K B B Pagnano Medical doctor

Dr H Malhotra Medical doctor

Company Secretary

Ms N C Evans

Independent Examiner

R Appleyard FCA

Gibbons Mannington & Phipps LLP

Chartered Accountants

20 Eversley Road

Bexhill-on-Sea

East Sussex

TN40 1HE

Bankers

HSBC Bank, 152 Portobello Road, London, W11 2EA

QUALIFYING THIRD PARTY INDEMNITY PROVISION

There is a qualifying third party indemnity in force at the date of approval of this report, for the benefit of every director or other officer or auditor.

This report has been prepared in accordance with the special provisions of Part 15 of the Companies Act 2006 relating to small companies.

Approved by order of the board of trustees on 3rd July 2026 and signed on its behalf by:

Professor J Cortes - Trustee

INDEPENDENT EXAMINER'S REPORT TO THE TRUSTEES OF

THE INTERNATIONAL CML FOUNDATION (REGISTERED NUMBER: 06996068)

Independent examiner's report to the trustees of The International CML Foundation ('the Company')

I report to the charity trustees on my examination of the accounts of the Company for the year ended 31st August 2025.

Responsibilities and basis of report

As the charity's trustees of the Company (and also its directors for the purposes of company law) you are responsible for the preparation of the accounts in accordance with the requirements of the Companies Act 2006 ('the 2006 Act').

Having satisfied myself that the accounts of the Company are not required to be audited under Part 16 of the 2006 Act and are eligible for independent examination, I report in respect of my examination of your charity's accounts as carried out under Section 145 of the Charities Act 2011 ('the 2011 Act'). In carrying out my examination I have followed the Directions given by the Charity Commission under Section 145(5) (b) of the 2011 Act.

Independent examiner's statement

Since your charity's gross income exceeded £250,000 your examiner must be a member of a listed body. I can confirm that I am qualified to undertake the examination because I am a member of the Institute of Chartered Accountants in England and Wales, which is one of the listed bodies.

I have completed my examination. I confirm that no matters have come to my attention in connection with the examination giving me cause to believe:

1. | accounting records were not kept in respect of the Company as required by Section 386 of the 2006 Act; or

2. | the accounts do not accord with those records; or

3. | the accounts do not comply with the accounting requirements of Section 396 of the 2006 Act other than any requirement that the accounts give a true and fair view which is not a matter considered as part of an independent examination; or

4. | the accounts have not been prepared in accordance with the methods and principles of the Statement of Recommended Practice for accounting and reporting by charities (applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102)).

I have no concerns and have come across no other matters in connection with the examination to which attention should be drawn in this report in order to enable a proper understanding of the accounts to be reached.

R Appleyard FCA

The Institute of Chartered Accountants in England and Wales

Gibbons Mannington & Phipps LLP

Chartered Accountants

20 Eversley Road

Bexhill-on-Sea

East Sussex

TN40 1HE

13th July 2026

THE INTERNATIONAL CML FOUNDATION

STATEMENT OF FINANCIAL ACTIVITIES

FOR THE YEAR ENDED 31ST AUGUST 2025

| 2025 |  | 2024

| Unrestricted |  | Restricted |  | Total |  | Total

| funds |  | funds |  | funds |  | funds

| Notes | £ | £ | £ | £ |

INCOME AND ENDOWMENTS FROM

Donations and legacies | 106,197 |  | 161,210 |  | 267,407 |  | 319,194 |

Other income | 2 | (6,233 | ) | - |  | (6,233 | ) | (8,700 | )

Total | 99,964 |  | 161,210 |  | 261,174 |  | 310,494 |

EXPENDITURE ON

Charitable activities

Preceptorships | - |  | - |  | - |  | 3,808 |

Diagnostics program | - |  | - |  | - |  | 11,841 |

Scientific meetings | - |  | - |  | - |  | 31,833 |

Clinical and Scientific communication | - |  | - |  | - |  | 66,157 |

Fundraising | 38,313 |  | - |  | 38,313 |  | 25,784 |

Cure Consortium | - |  | - |  | - |  | 1,820 |

Covid-19 & CML Study | - |  | - |  | - |  | 1,750 |

Knowledge Centre | - |  | - |  | - |  | 3,675 |

Clinical Conversations program | - |  | - |  | - |  | 11,585 |

RDG | - |  | - |  | - |  | 32,709 |

Alliances | - |  | - |  | - |  | 11,103 |

Education meetings | - |  | - |  | - |  | 21,959 |

Physian support, education and best practice sharing | 63,084 |  | 129,061 |  | 192,145 |  | - |

Scientific research | 7,290 |  | 54,218 |  | 61,508 |  | - |

Patient and carer support and education | 2,515 |  | 30,126 |  | 32,641 |  | - |

Admin / Governance | 17,357 |  | - |  | 17,357 |  | - |

Other | (1,980 | ) | - |  | (1,980 | ) | 14,998 |

Total | 126,579 |  | 213,405 |  | 339,984 |  | 239,022 |

NET INCOME/(EXPENDITURE) | (26,615 | ) | (52,195 | ) | (78,810 | ) | 71,472 |

RECONCILIATION OF FUNDS

Total funds brought forward | 30,933 |  | 232,595 |  | 263,528 |  | 192,056 |

TOTAL FUNDS CARRIED FORWARD | 4,318 |  | 180,400 |  | 184,718 |  | 263,528 |

THE INTERNATIONAL CML FOUNDATION (REGISTERED NUMBER: 06996068)

BALANCE SHEET

31ST AUGUST 2025

| 2025 |  | 2024

| Unrestricted |  | Restricted |  | Total |  | Total

| funds |  | funds |  | funds |  | funds

| Notes | £ | £ | £ | £ |

CURRENT ASSETS |

Debtors | 9 | 9,118 |  | 101,223 |  | 110,341 |  | 51,632 |

Cash at bank and in hand | - |  | 79,177 |  | 79,177 |  | 218,676 |

9,118 |  | 180,400 |  | 189,518 |  | 270,308 |

CREDITORS |

Amounts falling due within one year | 10 | (4,800 | ) | - |  | (4,800 | ) | (6,780 | )

NET CURRENT ASSETS | 4,318 |  | 180,400 |  | 184,718 |  | 263,528 |

TOTAL ASSETS LESS CURRENT LIABILITIES | 4,318 |  | 180,400 |  | 184,718 |  | 263,528 |

NET ASSETS | 4,318 |  | 180,400 |  | 184,718 |  | 263,528 |

FUNDS | 11

Unrestricted funds | 4,318 |  | 30,933 |

Restricted funds | 180,400 |  | 232,595 |

TOTAL FUNDS | 184,718 |  | 263,528 |

The charitable company is entitled to exemption from audit under Section 477 of the Companies Act 2006 for the year ended 31st August 2025.

The members have not required the company to obtain an audit of its financial statements for the year ended 31st August 2025 in accordance with Section 476 of the Companies Act 2006.

The trustees acknowledge their responsibilities for

(a) | ensuring that the charitable company keeps accounting records that comply with Sections 386 and 387 of the Companies Act 2006 and

(b) | preparing financial statements which give a true and fair view of the state of affairs of the charitable company as at the end of each financial year and of its surplus or deficit for each financial year in accordance with the requirements of Sections 394 and 395 and which otherwise comply with the requirements of the Companies Act 2006 relating to financial statements, so far as applicable to the charitable company.

These financial statements have been prepared in accordance with the provisions applicable to charitable companies subject to the small companies regime.

The financial statements were approved by the Board of Trustees and authorised for issue on 3rd July 2026 and were signed on its behalf by:

J Cortes - Trustee

THE INTERNATIONAL CML FOUNDATION

NOTES TO THE FINANCIAL STATEMENTS

FOR THE YEAR ENDED 31ST AUGUST 2025

1. | ACCOUNTING POLICIES

| Basis of preparing the financial statements

| The financial statements of the charitable company, which is a public benefit entity under FRS 102, have been prepared in accordance with the Charities SORP (FRS 102) 'Accounting and Reporting by Charities: Statement of Recommended Practice applicable to charities preparing their accounts in accordance with the Financial Reporting Standard applicable in the UK and Republic of Ireland (FRS 102) (effective 1 January 2019)', Financial Reporting Standard 102 'The Financial Reporting Standard applicable in the UK and Republic of Ireland' and the Companies Act 2006. The financial statements have been prepared under the historical cost convention.

| Income

| Items of income are recognised and included in the accounts when all of the following criteria

| are met:

| - |  | The charity or its subsidiary have entitlement to the funds; |  |

| - |  | any performance conditions attached to the item(s) of income have been met or are fully within the control of the charity or its subsidiary; |  |

| - |  | there is sufficient certainty that receipt of the income is considered probable; and |  |

| - |  | the amount can be measured reliably. |  |

| Expenditure

| Liabilities are recognised as expenditure as soon as there is a legal or constructive obligation committing the charity to that expenditure, it is probable that a transfer of economic benefits will be required in settlement and the amount of the obligation can be measured reliably. Expenditure is accounted for on an accruals basis and has been classified under headings that aggregate all cost related to the category. Where costs cannot be directly attributed to particular headings they have been allocated to activities on a basis consistent with the use of resources.

| Debtors

| Debtors are recognised at the settlement amount due after any trade discount offered. Prepayments are valued at the amount prepaid after taking account of any trade discounts due.

| Creditors and provisions

| Creditors and provisions are recognised where the charity has a present obligation resulting from a past event that will probably result in the transfer of funds to a third party and the amount due to settle the obligation can be measured or estimated reliably. Creditors and provisions are normally recognised at their settlement amount after allowing for any trade discounts due.

| Taxation

| The charity is exempt from corporation tax on its charitable activities.

| Fund accounting

| Unrestricted funds can be used in accordance with the charitable objectives at the discretion of the trustees.

| Restricted funds can only be used for particular restricted purposes within the objects of the charity. Restrictions arise when specified by the donor or when funds are raised for particular restricted purposes.

| Further explanation of the nature and purpose of each fund is included in the notes to the financial statements.

| Foreign currencies

| Assets and liabilities in foreign currencies are translated into sterling at the rates of exchange ruling at the balance sheet date. Transactions in foreign currencies are translated into sterling at the rate of exchange ruling at the date of transaction. Exchange differences are taken into account in arriving at the operating result and are shown as other income.

THE INTERNATIONAL CML FOUNDATION

NOTES TO THE FINANCIAL STATEMENTS - continued

FOR THE YEAR ENDED 31ST AUGUST 2025

2. | OTHER INCOME

| Other income consists of the profit/loss on foreign currency exchange in accordance with the accounting policy on foreign exchange transactions.

3. | SUPPORT COSTS

| Management |  | Governance |

| fees |  | Finance |  | Other |  | costs |  | Totals

£ | £ | £ | £ | £ |

| Other resources expended | - |  | - |  | - |  | (1,980 | ) | (1,980 | ) |

| Fundraising | 31,203 |  | - |  | 1,877 |  | - |  | 33,080 |  |

| Physian support, education and best practice sharing | 116,842 |  | 50 |  | - |  | - |  | 116,892 |  |

| Scientific research | 23,474 |  | - |  | - |  | - |  | 23,474 |  |

| Patient and carer support and education | 14,088 |  | - |  | - |  | - |  | 14,088 |  |

| Admin / Governance | 9,789 |  | 490 |  | 144 |  | 6,540 |  | 16,963 |  |

195,396 |  | 540 |  | 2,021 |  | 4,560 |  | 202,517 |  |

| Support costs, included in the above, are as follows: |

| Management fees |

| Physian |

| support, |

| education |

| and best |

| practice |  | Scientific

| Fundraising |  | sharing |  | research

£ | £ | £ |

| Management & admin | 31,203 |  | 116,842 |  | 23,474 |  |

| 2025 |  | 2024

| Patient |

| and carer |

| support |

| and |  | Admin / |  | Total |  | Total

| education |  | Governance |  | activities |  | activities

£ | £ | £ | £ |

| Management & admin | 14,088 |  | 9,789 |  | 195,396 |  | 192,302 |  |

| Finance |

| 2025 |  | 2024

| Physian |

| support, |

| education |

| and best |

| practice |  | Admin / |  | Total |  | Total

| sharing |  | Governance |  | activities |  | activities

£ | £ | £ | £ |

| Bank charges | 50 |  | 490 |  | 540 |  | 545 |  |

THE INTERNATIONAL CML FOUNDATION

NOTES TO THE FINANCIAL STATEMENTS - continued

FOR THE YEAR ENDED 31ST AUGUST 2025

3. | SUPPORT COSTS - continued

| Other |

| 2025 |  | 2024

| Admin / |  | Total |  | Total

| Fundraising |  | Governance |  | activities |  | activities

£ | £ | £ | £ |

| Sundry office costs | 1,877 |  | 144 |  | 2,021 |  | 3,273 |  |

| Governance costs |

| 2025 |  | 2024

| Other |

| resources |  | Admin / |  | Total |  | Total

| expended |  | Governance |  | activities |  | activities

£ | £ | £ | £ |

| Accountancy - Independent examination fee | (1,980 | ) | 6,540 |  | 4,560 |  | 4,596 |  |

4. | NET INCOME/(EXPENDITURE)

| Net income/(expenditure) is stated after charging/(crediting): |

| 2025 |  | 2024

£ | £ |

| Accountancy - Independent examination fee | 4,560 |  | 4,596 |  |

5. | TRUSTEES' REMUNERATION AND BENEFITS

| There were no trustees' remuneration or other benefits for the year ended 31st August 2025 nor for the year ended 31st August 2024.

| Trustees' expenses

| There were no trustees' expenses paid for the year ended 31st August 2025 nor for the year ended 31st August 2024.

6. | STAFF COSTS

| The average monthly number of employees during the year was as follows:

| 2025 |  | 2024

| Charitable activities | 6 |  | 6 |  |

| The number of employees whose employee benefits (excluding employer pension costs) exceeded £60,000 was:

| 2025 |  | 2024

| £80,001 - £90,000 | 1 |  | 1 |  |

THE INTERNATIONAL CML FOUNDATION

NOTES TO THE FINANCIAL STATEMENTS - continued

FOR THE YEAR ENDED 31ST AUGUST 2025

7. | COMPARATIVES FOR THE STATEMENT OF FINANCIAL ACTIVITIES

| Unrestricted |  | Restricted |  | Total

| funds |  | funds |  | funds

£ | £ | £ |

| INCOME AND ENDOWMENTS FROM

| Donations and legacies | 104,927 |  | 214,267 |  | 319,194 |

| Other income | (8,700 | ) | - |  | (8,700 | )

| Total | 96,227 |  | 214,267 |  | 310,494 |

| EXPENDITURE ON

| Charitable activities

| Preceptorships | 3,808 |  | - |  | 3,808 |

| Diagnostics program | - |  | 11,841 |  | 11,841 |

| Scientific meetings | 31,833 |  | - |  | 31,833 |

| Clinical and Scientific communication | 35,060 |  | 31,097 |  | 66,157 |

| Fundraising | 25,784 |  | - |  | 25,784 |

| Cure Consortium | - |  | 1,820 |  | 1,820 |

| Covid-19 & CML Study | 1,750 |  | - |  | 1,750 |

| Knowledge Centre | 3,675 |  | - |  | 3,675 |

| Clinical Conversations program | 11,585 |  | - |  | 11,585 |

| RDG | 17,160 |  | 15,549 |  | 32,709 |

| Alliances | - |  | 11,103 |  | 11,103 |

| Education meetings | 1,554 |  | 20,405 |  | 21,959 |

| Other | 14,998 |  | - |  | 14,998 |

| Total | 147,207 |  | 91,815 |  | 239,022 |

| NET INCOME/(EXPENDITURE) | (50,980 | ) | 122,452 |  | 71,472 |

| RECONCILIATION OF FUNDS

| Total funds brought forward | 81,912 |  | 110,144 |  | 192,056 |

| TOTAL FUNDS CARRIED FORWARD | 30,932 |  | 232,596 |  | 263,528 |

8. | VOLUNTEERS

| The charity heavily relies upon the many medical professionals who donate their time to help run the various charitable activities undertaken. It is not possible to accurately calculate the value of the services contributed by these volunteers and therefore the numbers do not reflect either the income or expenditure, however it is thought to be in the region of £230,000.

THE INTERNATIONAL CML FOUNDATION

NOTES TO THE FINANCIAL STATEMENTS - continued

FOR THE YEAR ENDED 31ST AUGUST 2025

9. | DEBTORS: AMOUNTS FALLING DUE WITHIN ONE YEAR

2025 | 2024 |

£ | £ |

| Other debtors | 21,209 |  | 51,632 |  |

| Prepayments and accrued income | 89,132 |  | - |  |

110,341 |  | 51,632 |  |

| Included within other debtors is a balance of £757 (2024 - £49,997) in respect of funds held by Paypal.

10. | CREDITORS: AMOUNTS FALLING DUE WITHIN ONE YEAR

2025 | 2024 |

£ | £ |

| Accrued expenses | 4,800 |  | 6,780 |  |

11. | MOVEMENT IN FUNDS

| Net |  |

| movement |  | At |

| At 1/9/24 |  | in funds |  | 31/8/25 |

£ | £ | £ |

| Unrestricted funds

| General fund | 30,933 |  | (26,615 | ) | 4,318 |  |

| Restricted funds

| Novartis Pharmaceuticals Corporation | 91,250 |  | (42,029 | ) | 49,221 |  |

| Novartis - Knowledge | - |  | 760 |  | 760 |  |

| Incyte - Alliance/Cure Programs | 111,218 |  | (54,217 | ) | 57,001 |  |

| Patient Education | 30,127 |  | (30,127 | ) | - |  |

| Novartis Chile | - |  | 1,063 |  | 1,063 |  |

| Novartis Saudi | - |  | 72,355 |  | 72,355 |  |

232,595 |  | (52,195 | ) | 180,400 |  |

| TOTAL FUNDS | 263,528 |  | (78,810 | ) | 184,718 |  |

| Net movement in funds, included in the above are as follows:

| Incoming |  | Resources |  | Movement |

| resources |  | expended |  | in funds |

£ | £ | £ |

| Unrestricted funds

| General fund | 99,964 |  | (126,579 | ) | (26,615 | ) |

| Restricted funds

| Novartis Pharmaceuticals Corporation | - |  | (42,029 | ) | (42,029 | ) |

| Novartis - Knowledge | 72,077 |  | (71,317 | ) | 760 |  |

| Incyte - Alliance/Cure Programs | 1 |  | (54,218 | ) | (54,217 | ) |

| Patient Education | - |  | (30,127 | ) | (30,127 | ) |

| Novartis Chile | 9,235 |  | (8,172 | ) | 1,063 |  |

| Novartis Saudi | 79,897 |  | (7,542 | ) | 72,355 |  |

161,210 |  | (213,405 | ) | (52,195 | ) |

| TOTAL FUNDS | 261,174 |  | (339,984 | ) | (78,810 | ) |

THE INTERNATIONAL CML FOUNDATION

NOTES TO THE FINANCIAL STATEMENTS - continued

FOR THE YEAR ENDED 31ST AUGUST 2025

11. | MOVEMENT IN FUNDS - continued

| Comparatives for movement in funds

| Net |  |

| movement |  | At |

| At 1/9/23 |  | in funds |  | 31/8/24 |

£ | £ | £ |

| Unrestricted funds

| General fund | 81,912 |  | (50,979 | ) | 30,933 |  |

| Restricted funds

| Novartis Pharmaceuticals Corporation | 103,090 |  | (11,840 | ) | 91,250 |  |

| Pfizer Grant | 7,054 |  | (7,054 | ) | - |  |

| Incyte - Alliance/Cure Programs | - |  | 111,218 |  | 111,218 |  |

| Patient Education | - |  | 30,127 |  | 30,127 |  |

110,144 |  | 122,451 |  | 232,595 |  |

| TOTAL FUNDS | 192,056 |  | 71,472 |  | 263,528 |  |

| Comparative net movement in funds, included in the above are as follows:

| Incoming |  | Resources |  | Movement |

| resources |  | expended |  | in funds |

£ | £ | £ |

| Unrestricted funds

| General fund | 96,227 |  | (147,206 | ) | (50,979 | ) |

| Restricted funds

| Novartis Pharmaceuticals Corporation | 1 |  | (11,841 | ) | (11,840 | ) |

| Takeda Oncology | 31,097 |  | (31,097 | ) | - |  |

| Pfizer Grant | - |  | (7,054 | ) | (7,054 | ) |

| Incyte - Alliance/Cure Programs | 117,088 |  | (5,870 | ) | 111,218 |  |

| Patient Education | 50,532 |  | (20,405 | ) | 30,127 |  |

| Novartis RDG | 15,549 |  | (15,549 | ) | - |  |

214,267 |  | (91,816 | ) | 122,451 |  |

| TOTAL FUNDS | 310,494 |  | (239,022 | ) | 71,472 |  |

THE INTERNATIONAL CML FOUNDATION

NOTES TO THE FINANCIAL STATEMENTS - continued

FOR THE YEAR ENDED 31ST AUGUST 2025

11. | MOVEMENT IN FUNDS - continued

| A current year 12 months and prior year 12 months combined position is as follows:

| Net |  |

| movement |  | At |

| At 1/9/23 |  | in funds |  | 31/8/25 |

£ | £ | £ |

| Unrestricted funds

| General fund | 81,912 |  | (77,594 | ) | 4,318 |  |

| Restricted funds

| Novartis Pharmaceuticals Corporation | 103,090 |  | (53,869 | ) | 49,221 |  |

| Pfizer Grant | 7,054 |  | (7,054 | ) | - |  |

| Novartis - Knowledge | - |  | 760 |  | 760 |  |

| Incyte - Alliance/Cure Programs | - |  | 57,001 |  | 57,001 |  |

| Novartis Chile | - |  | 1,063 |  | 1,063 |  |

| Novartis Saudi | - |  | 72,355 |  | 72,355 |  |

110,144 |  | 70,256 |  | 180,400 |  |

| TOTAL FUNDS | 192,056 |  | (7,338 | ) | 184,718 |  |

| A current year 12 months and prior year 12 months combined net movement in funds, included in the above are as follows:

| Incoming |  | Resources |  | Movement |

| resources |  | expended |  | in funds |

£ | £ | £ |

| Unrestricted funds

| General fund | 196,191 |  | (273,785 | ) | (77,594 | ) |

| Restricted funds

| Novartis Pharmaceuticals Corporation | 1 |  | (53,870 | ) | (53,869 | ) |

| Takeda Oncology | 31,097 |  | (31,097 | ) | - |  |

| Pfizer Grant | - |  | (7,054 | ) | (7,054 | ) |

| Novartis - Knowledge | 72,077 |  | (71,317 | ) | 760 |  |

| Incyte - Alliance/Cure Programs | 117,089 |  | (60,088 | ) | 57,001 |  |

| Patient Education | 50,532 |  | (50,532 | ) | - |  |

| Novartis RDG | 15,549 |  | (15,549 | ) | - |  |

| Novartis Chile | 9,235 |  | (8,172 | ) | 1,063 |  |

| Novartis Saudi | 79,897 |  | (7,542 | ) | 72,355 |  |

375,477 |  | (305,221 | ) | 70,256 |  |

| TOTAL FUNDS | 571,668 |  | (579,006 | ) | (7,338 | ) |

THE INTERNATIONAL CML FOUNDATION

NOTES TO THE FINANCIAL STATEMENTS - continued

FOR THE YEAR ENDED 31ST AUGUST 2025

12. | RELATED PARTY DISCLOSURES

| There were no related party transactions for the year ended 31st August 2025.